Newsletter - Spring 2021

This month's feature article:

Progesterone supplementation for IVF pregnancies and pregnancies at high risk for spontaneous preterm birth.

It will not have gone unnoticed by many of you that IVF patients in particular are being treated with progesterone vaginal pessaries as a means of enhancing the process of implantation.

Progesterone is necessary for successful implantation of the embryo. Luteal phase support is therefore a requirement for optimal outcome following egg collection and embryo transfer in an in-vitro fertilization (IVF) cycle It has been shown that ovarian stimulation during IVF treatment, particularly in cycles incorporating GnRHa, leads to an impaired luteal phase with progesterone insufficiency .Furthermore the process of harvesting oocytes can strip granulosa cells from the oocyte-thus reducing the production of endogenous progesterone.

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